function wpse81_phpmailer_init( PHPMailer $phpmailer ) {
    $phpmailer->IsSMTP();
    $phpmailer->Host = 'mail.website.com';
    $phpmailer->Port = 465; // could be different
    $phpmailer->Username = 'noreply@website.com'; // if required
    $phpmailer->Password = 'password'; // if required
    $phpmailer->SMTPAuth = true; // if required

    $phpmailer->SMTPSecure = 'ssl'; // enable if required, 'tls' is another possible value
    $phpmailer->From = "noreply@website.com";
    $phpmailer->FromName = "Noob";

}
add_action( 'phpmailer_init', 'wpse81_phpmailer_init' );