class test_button:
def __init__(self, master):
    self.master = master
    self.next_button = None

    if not (self.next_button):
        self.next_button = Button(root, background="orange red", activebackground="orangered3", text="Next Test Config", command=self.next_button_code).grid(row=1, column=1)

 def next_button_code(self):
     if self.next_button:
         self.next_button.destroy(); self.next_button = None

# Top Local Variables
root = Tk()

# Top Level Default Codes
my_gui = test_button(root)

root.mainloop()