Thanks for the replies. I ended up reinstalling vpopmail with yum so it would grab the iworx version and it seemed to of fixed the user and group for all the directories and files. I'm still getting the same error though :/

I went ahead after that and ran both of your suggests and I'm still having the same problem. And to answer your question, it's across all domains. We have roughly 25 domains on the server.

Also, it seems that another problem has come up. Now, my local qmail queue isn't processing.

Here is the maillog:

[CODE] ****** maildrop[10688]: Unable to open filter file, errno=13.[/CODE]

So...now, we aren't getting our email too. They may not be related but it almost seems like everything is falling apart at one time, lol. I will say, it looked like something happened to my group file because the vchkpw group was missing altogether until I reinstalled vpopmail. I'm not sure what happened there. I never manually update the groups.