# THE DIR IS TAB COMPLETED
sudo mono tuxlol.exe patch -d ~/.PlayOnLinux/wineprefix/LeagueOfLegends/drive_c/Riot\ Games/League\ of\ Legends/
The specified directory is invalid. 

# SOURCE ####
http://www.ugopiemontese.eu/2014/05/31/league-of-legends-ubuntu-14-04/
# CONTENTS
Install mono and libmono-system-core4.0-cil
sudo apt-get install mono-runtime libmono-system-core4.0-cil
Download TuxLoL: https://bitbucket.org/Xargoth/tuxlol/wiki/Home or direct link
Unzip the archive anywhere you want
Enter the folder where you just unzipped it (you will see the tuxlol.exe file) and execute it with
mono tuxlol.exe patch --dir LEAGUE_OF_LEGENDS_DIR