httpd.conf: WSGIScriptAlias /treeio /var/www/treeio/wsgi.py WSGIPythonPath /var/www/treeio Order deny,allow Allow from all ------ /var/www/treeio/wsgi.py: import os os.environ.setdefault("DJANGO_SETTINGS_MODULE", "settings") from django.core.wsgi import get_wsgi_application application = get_wsgi_application()