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struct MyITKPipelineInterface
{
  virtual void setParam(int param) = 0;
  virtual void update() = 0;
};

template<typename TPixel, unsigned int VImageDimension>
struct MyITKPipeline : public MyITKPipelineInterface
{
  typedef itk::Image<TPixel, VImageDimension> ImageType;
  itk::Filter1<ImageType>::Pointer firstFilter;
  ...
  itk::Filter5<ImageType>::Pointer lastFilter;

  MyITKPipeline() { ... initialize stuff and connect pipeline ... }

  void setParam(int param) {
    firstFilter->setParam(param);
  }

  void update() {
    lastFilter->Update();
  }
};

class CalculateSomething
{

public:

void CreateSegmenation()
{
  AccessByItk(mitkImage, InvokeITKPipeline)
}

private:

std::map<std::string, MyITKPipelineInterface*> typeToPipelineMap;

template<typename TPixel, unsigned int VImageDimension>
void InvokeITKPipeline(itk::Image<TPixel, VImageDimension>* itkImage)
{
  std::stringstream key;
  key << typeid(TPixel).name() << VImageDimension;

  MyITKPipelineInterface* myPipeline = typeToPipelineMap[key];
  if (myPipeline == 0)
  {
    MyITKPipeline<TPixel, VImageDimension>* pipeline = new MyITKPipeline<TPixel, VImageDimension>();
    pipeline->firstFilter.SetInput(itkImage);
    myPipeline = pipeline;
    typeToPipelineMap[key] = myPipeline;
    // get the output pointer and save it in some mitk::Image
  }

  myPipeline->setParam(4);
  myPipeline->update();
}

};