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By: a guest on Apr 25th, 2012  |  syntax: None  |  size: 1.43 KB  |  hits: 14  |  expires: Never
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  1. ### START STATEMENT GROUP ###
  2. SET STATEMENT_GROUP = "Group 1"
  3.  
  4. SET Disease = "Atherosclerosis"
  5. SET Evidence = "Oxidation and nitration of macromolecules, such as proteins, DNA and lipids, are prominent
  6. in atherosclerotic arteries."
  7.  
  8. pathology(MESHD:Atherosclerosis) positiveCorrelation biologicalProcess(GO:"lipid oxidation")
  9. pathology(MESHD:Atherosclerosis) positiveCorrelation biologicalProcess(GO:"protein oxidation")
  10.  
  11. SET Evidence = "Arterial cells are highly susceptible to oxidative stress, which can induce both necrosis
  12. and apoptosis (programmed cell death) [1,2]"
  13.  
  14. biologicalProcess(GO:"response to oxidative stress") increases biologicalProcess(GO:"apoptotic process")
  15. biologicalProcess(GO:"response to oxidative stress") increases biologicalProcess(GO:necrosis)
  16.  
  17. UNSET STATEMENT_GROUP
  18. ### END STATEMENT GROUP ###
  19.  
  20.  
  21.  
  22. ### START STATEMENT GROUP ###
  23. SET STATEMENT_GROUP = "Group 2"
  24.  
  25. SET Evidence = "Phosphorylation at Ser473, along with Thr308 of its activation loop, is deemed necessary
  26. for Akt function, although the regulatory mechanisms and physiological importance
  27. of each phosphorylation site remain to be fully understood."
  28.  
  29. proteinAbundance(HGNC:AKT1,proteinModification(P,T,308)) directlyIncreases kinaseActivity(proteinAbundance(HGNC:AKT1))
  30. proteinAbundance(HGNC:AKT1,proteinModification(P,S,473)) directlyIncreases kinaseActivity(proteinAbundance(HGNC:AKT1))
  31.  
  32. UNSET STATEMENT_GROUP
  33. ### END STATEMENT GROUP ###
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