using (SPSite site = new SPSite("siteurl"))
{
  SPServiceContext context = SPServiceContext.GetContext(site);
  UserProfileManager profileManager = new UserProfileManager(context);
  userprofile = profileManager.GetUserProfile(domainAccount);
  if (this.userprofile["SPS-JobTitle"] != null)
  {
    jobtitle = Convert.ToString(this.userprofile["SPS-JobTitle"].Value);
  }
}