SPSecurity.RunWithElevatedPrivileges(delegate()
        {
            string siteUrl = SPContext.Current.Web.Url;

            using (SPSite siteCollection = new SPSite(siteUrl))
            {

                SPServiceContext serviceContext = SPServiceContext.GetContext(siteCollection);
                UserProfileManager userProfileMgr = new UserProfileManager(serviceContext);
                UserProfile userProfile = userProfileMgr.GetUserProfile(true);
                try
                {
                    userProfile["SkypeAccount"].Value = "test";
                    userProfile.Commit();
                }
                catch { }


                try
                {
                    userProfile["WorkPhone"].Value = "12345678";
                    userProfile.Commit();
                }
                catch { }
            }
        });